Thermodynamic Study on the Amorphous Form and Crystalline Hydrates Using in Situ Raman and FBRM

The solubilities and maximum supersaturation concentrations of an amorphous the crystalline tetrahydrate heptahydrate solids disodium guanosine 5'-monophosphate (GMP) in water-methanol mixtures were measured situ by Raman spectroscopy focused beam reflectance measurement. distinct peaks form, hydrates, solution, solvent used for measurements solubility supersaturation. Above 45 °C at methanol fractions 0.15–0.90, was stable while below 40 0.15–0.60, form. Especially, fraction > 0.7 temperature investigated. supersaturated concentration values can be to selectively produce amorphous, tetrahydrate, GMP anti-solvent crystallization.